Workpackage 6: Training

Workpackage Leader: Prof. Dr. Anett Schallmey Lead beneficiary: TU Braunschweig -Prof. Anett Schallmey is the training manager. She is supported by the Project Manager. -Career development is monitored by career development plans. Supervision of all ESRs is monitored by supervision agreements and career plans ESRs participate in graduate schools at KTH, RUB, UGR, UOV and […]

Workpackage 5: Management

Project Coordinator: Jun.-Prof. Robert Kourist Coordinating Insitution: Ruhr University Bochum Project Manager: Julirose Gonzales

Workpackage 4: Transaminase tandem reactions employing metal and organo catalysts

Workpackage Leader: Prof. Dr. Harald Gröger Lead beneficiary: University Bielefeld Participating Partners: Entrechem, DSM, KTH, TU Graz Start month: 7 End month: 42 One-pot C–C coupling and transamination: For cascade 6, a careful analysis of parameters limiting compatibility of the second step of the reaction will be performed. Both, the chemical and the enzymatic steps […]

Workpackage 3: Transaminase-catalyzed multi-enzyme cascade reactions

Workpackage Leader: Jun.-Prof. Dr. Matthias Höhne Lead beneficiary: Ernst-Moritz-Arndt-Universität Greifswald Participating Partners: Entrechem, SARomics, Enzymicals, KTH, Viazym Start month: 7 End month: 42 Novel equilibrium shift strategies: ESR 6 investigates novel achiral amine-donors, such as α,ω-diamines, (NH2-(CH2)n-NH2; n=2-5) and ω-aminoalkan-1-ols (NH2-(CH2)n-NH2; n=4-5) and the oxidation of the formed hemiacetal byproduct by a dehydrogenase to efficiently […]

Workpackage 2: Enantiopure 1,3/1,4-amino acids and amino alcohols from prochiral ketoacids

Workpackage Leader: Jun.-Prof. Dr. Robert Kourist Lead beneficiary: Ruhr University Bochum Participating Partners: Entrechem, SARomics, DSM, Viazym Start month: 7 End month: 42 WP2 focuses on the synthesis of enantiopure 1,3- and 1,4-aminoacids: ESR4 develops a two-enzyme cascade combining amino acid α- aminotransferase (AAT) and aminoacid hydroxylase (AAH) to convert readily available keto acid precursors […]

Workpackage 1: Enantiopure 1,2-aminoalcohols from achiral substrates

Workpackage Leader: Prof. Dr. Anett Schallmey Lead beneficiary: TU Braunschweig Participating Partners: Enzymicals, Viazym, TU Delft Start month: 7 End month: 42 Two novel cascades for the synthesis of enantiomerically pure 1,2-aminoalcohols, important precursors of various pharmaceuticals such as β- blockers, will be established starting either from prochiral ketones or achiral alkenes. In the first […]