Synthesis of enantiopure 1,2-aminoalcohols from ketones

Fellow: ESR1
Host Institution: Viazym- the Netherlands
Secondments: TU Delft- the Netherlands and TU Braunschweig- Germany
Supervisors: L. van Langen (Viazym), F. Hollmann (TU Delft), A. Schallmey (TU Braunschweig)

This PhD will focus on the microcompartimentalization of Pd nanoparticles for combination with enzymes in cascade reactions. The ESR is expected to identify optimal reaction parameters and upscale the full cascade for proof-of principle.

Objectives
1. Micro-compartmentalization of Pd nanoparticles for combination with enzymes in cascade reactions
2. Proof-of-concept for peroxidase-catalyzed partial haloform reaction of methyl ketones
3. Identification of optimal peroxidases (with respect to activity and compatibility to the cascade envisaged)
4. Identification of optimal reaction parameters and upscaling of the full cascade for proof-of-principle in 10 g-scale, cost-benefit analysis

The Biocascades Project is a joint collaboration among the following university and industrial partners