Synthesis of enantiopure 1,2-aminoalcohols from α-haloketones

Fellow: ESR2
Host Institution: Enzymicals
Supervisors: R. Wardenga (Enzymicals), F. Hollmann (TU Delft)

This PhD will focus on the optimization of one pot synthesis sequence and enzyme production. The ESR is expected to produce Enantio- and/or diastereomerically pure 1,2-aminoalcohols at preparative scale.

Objectives
1. Optimization of the one pot synthesis sequence (reaction conditions, enzyme formulation)
2. Optimization of enzyme production in 50 L-scale
3. Process intensification (at least 250 mM starting material for economically feasible processes)
4. Upscaling of the optimized sequence to 100 g-scale for demonstration of industrial noradrenaline synthesis and preparation of a “tech transfer package” for licensing

The Biocascades Project is a joint collaboration among the following university and industrial partners